Beginning in mid-February 2008, the 1997-2007 online version of the Science Watch® newsletter, ESI-Topics.com, and in-cites.com, will all be featured together on the redesigned ScienceWatch.com. All previous content from the three sites will be permanently archived, and remain accessible from any existing bookmarks to the archived pages. No new content will be added to this site. Updates and new content (updated biweekly) are available at ScienceWatch.com now.

Research Front Map

Molecular Biology & Genetics

Return to menu of Emerging Research Fronts

ESI Special Topics, October 2006
Citing URL: http://www.esi-topics.com/erf/maps/october2006-map.html
   

This Research Front on MAMMALIAN EXONIC SPLICING ENHANCERS from the field of Molecular Biology & Genetics was selected for mapping from the list of Emerging Research Fronts for October 2006 (data from the third bimonthly period of 2006). The map is a diagrammatic representation of the 22 core papers comprising the front. Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in red.


Emerging Research Fronts Comments
Laurence D. Hurst discuss his highly cited paper, "Hearing silence: non-neutral evolution at synonymous sites in mammals," (CNAT REV GENET, 7 (2): 98-108 FEB 2006) which is this month's emerging research front in Molecular Biology & Genetics. This paper is also represented in the map below.

Brett-2000 Smith-2000 Graveley-2000 Graveley-2001 Modrek-2001 Cartegni-2002 Caceres-2002 Maniatis-2002 Faustino-2003 Cartegni-2003 Black-2003 Johnson-2003 Thanaraj-2004 Garcia-Blanco-2004 Buratti-2004 Wang-2004 Pan-2004 Nagasaki-2005 Parmley-2006 Chamary-2006 Ohler-2005 Su-2006

 MAMMALIAN EXONIC SPLICING ENHANCERS  


 Core Papers 


Label: Cartegni-2002
Title: Listening to silence and understanding nonsense: Exonic mutations that affect splicing
Journal: NAT REV GENET, 3 (4): 285-298 APR 2002
Citations: 411
Authors: Cartegni, L;Chew, SL;Krainer, AR
Addresses:
Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England


[Back to Map]     

Label: Graveley-2000
Title: Sorting out the complexity of SR protein functions
Journal: RNA, 6 (9): 1197-1211 SEP 2000
Citations: 336
Authors: Graveley, BR
Addresses:
Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, 263 Farmington Ave, Farmington, CT 06030 USA
Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA


[Back to Map]     

Label: Smith-2000
Title: Alternative pre-mRNA splicing: the logic of combinatorial control
Journal: TRENDS BIOCHEM SCI, 25 (8): 381-388 AUG 2000
Citations: 327
Authors: Smith, CWJ;Valcarcel, J
Addresses:
Univ Cambridge, Dept Biochem, 80 Tennis Court Rd,Old Addenbrookes Site, Cambridge CB2 1GA, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
European Mol Biol Lab, Gene Express Biol Lab, D-69117 Heidelberg, Germany


[Back to Map]     

Label: Graveley-2001
Title: Alternative splicing: increasing diversity in the proteomic world
Journal: TRENDS GENET, 17 (2): 100-107 FEB 2001
Citations: 277
Authors: Graveley, BR
Addresses:
Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA
Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA


[Back to Map]     

Label: Black-2003
Title: Mechanisms of alternative pre-messenger RNA splicing
Journal: ANNU REV BIOCHEM, 72: 291-336 2003
Citations: 245
Authors: Black, DL
Addresses:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Microbiol Immunol & Mol Genet, 6-762 MacDonald Bldg,Box 951662,675 Charles Young, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA


[Back to Map]     

Label: Modrek-2001
Title: Genome-wide detection of alternative splicing in expressed sequences of human genes
Journal: NUCL ACID RES, 29 (13): 2850-2859 JUL 1 2001
Citations: 223
Authors: Modrek, B;Resch, A;Grasso, C;Lee, C
Addresses:
Univ Calif Los Angeles, Dept Chem & Biochem, 611 Charles E Young Dr E, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA


[Back to Map]     

Label: Johnson-2003
Title: Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
Journal: SCIENCE, 302 (5653): 2141-2144 DEC 19 2003
Citations: 204
Authors: Johnson, JM;Castle, J;Garrett-Engele, P;Kan, ZY;Loerch, PM;Armour, CD;Santos, R;Schadt, EE;Stoughton, R;Shoemaker, DD
Addresses:
Merck & Co Inc, Rosetta Inpharmat LLC, 115th Ave NE, Kirkland, WA 98034 USA
Merck & Co Inc, Rosetta Inpharmat LLC, Kirkland, WA 98034 USA


[Back to Map]     

Label: Maniatis-2002
Title: Alternative pre-mRNA splicing and proteome expansion in metazoans
Journal: NATURE, 418 (6894): 236-243 JUL 11 2002
Citations: 199
Authors: Maniatis, T;Tasic, B
Addresses:
Harvard Univ, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA
Harvard Univ, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA


[Back to Map]     

Label: Faustino-2003
Title: Pre-mRNA splicing and human disease
Journal: GENE DEVELOP, 17 (4): 419-437 FEB 15 2003
Citations: 179
Authors: Faustino, NA;Cooper, TA
Addresses:
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
Univ Oporto, ICBAS, Grad Program Basic & Appl Biol, P-4003 Oporto, Portugal


[Back to Map]     

Label: Caceres-2002
Title: Alternative splicing: multiple control mechanisms and involvement in human disease
Journal: TRENDS GENET, 18 (4): 186-193 APR 2002
Citations: 170
Authors: Caceres, JF;Kornblihtt, AR
Addresses:
Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina


[Back to Map]     

Label: Brett-2000
Title: EST comparison indicates 38% of human mRNAs contain possible alternative splice forms
Journal: FEBS LETT, 474 (1): 83-86 MAY 26 2000
Citations: 148
Authors: Brett, D;Hanke, J;Lehmann, G;Haase, S;Delbruck, S;Krueger, S;Reich, J;Bork, P
Addresses:
Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13125 Berlin, Germany
Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
AGOWA GmbH, D-12489 Berlin, Germany
European Mol Biol Lab, D-69012 Heidelberg, Germany
GenProfile AG, D-13125 Berlin, Germany


[Back to Map]     

Label: Cartegni-2003
Title: ESEfinder: a web resource to identify exonic splicing enhancers
Journal: NUCL ACID RES, 31 (13): 3568-3571 JUL 1 2003
Citations: 148
Authors: Cartegni, L;Wang, JH;Zhu, ZW;Zhang, MQ;Krainer, AR
Addresses:
Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA


[Back to Map]     

Label: Garcia-Blanco-2004
Title: Alternative splicing in disease and therapy
Journal: NAT BIOTECHNOL, 22 (5): 535-546 MAY 2004
Citations: 62
Authors: Garcia-Blanco, MA;Baraniak, AP;Lasda, EL
Addresses:
Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Box 3053,Res Dr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr RNA Biol, Durham, NC 27710 USA


[Back to Map]     

Label: Thanaraj-2004
Title: ASD: the Alternative Splicing Database
Journal: NUCL ACID RES, 32: D64-D69 Sp. Iss. SI JAN 1 2004
Citations: 54
Authors: Thanaraj, TA;Stamm, S;Clark, F;Riethoven, JJ;Le Texier, V;Muilu, J
Addresses:
European Bioinformat Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England
European Bioinformat Inst, Cambridge CB10 1SD, England
Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany
Univ Queensland, Adv Computat Modelling Ctr, St Lucia, Qld 4072, Australia


[Back to Map]     

Label: Wang-2004
Title: Systematic identification and analysis of exonic splicing silencers
Journal: CELL, 119 (6): 831-845 DEC 17 2004
Citations: 46
Authors: Wang, ZF;Rolish, ME;Yeo, G;Tung, V;Mawson, M;Burge, CB
Addresses:
MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA


[Back to Map]     

Label: Pan-2004
Title: Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform
Journal: MOL CELL, 16 (6): 929-941 DEC 22 2004
Citations: 32
Authors: Pan, Q;Shai, O;Misquitta, C;Zhang, W;Saltzman, AL;Mohammad, N;Babak, T;Siu, H;Hughes, TR;Morris, QD;Frey, BJ;Blencowe, BJ
Addresses:
Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, 112 Coll St, Toronto, ON M5G 1L6, Canada
Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
Univ Toronto, Charles H Best Inst, Dept Elect & Comp Engn, Toronto, ON M5G 1L6, Canada
Univ Toronto, Charles H Best Inst, Dept Mol & Med Genet, Toronto, ON M5G 1L6, Canada
Univ Toronto, Charles H Best Inst, Program Prote & Bioinformat, Toronto, ON M5G 1L6, Canada


[Back to Map]     

Label: Buratti-2004
Title: Influence of RNA secondary structure on the pre-mRNA splicing process
Journal: MOL CELL BIOL, 24 (24): 10505-10514 DEC 2004
Citations: 28
Authors: Buratti, E;Baralle, FE
Addresses:
Padriciano 99, I-34012 Trieste, Italy
Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy


[Back to Map]     

Label: Chamary-2006
Title: Hearing silence: non-neutral evolution at synonymous sites in mammals
Journal: NAT REV GENET, 7 (2): 98-108 FEB 2006
Citations: 9
Authors: Chamary, JV;Parmley, JL;Hurst, LD
Addresses:
Univ Lausanne, Ctr Integrat Genom, Genopode Bldg, CH-1015 Lausanne, Switzerland
Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland
Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England


[Back to Map]     

Label: Parmley-2006
Title: Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers
Journal: MOL BIOL EVOL, 23 (2): 301-309 FEB 2006
Citations: 5
Authors: Parmley, JL;Chamary, JV;Hurst, LD
Addresses:
Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England


[Back to Map]     

Label: Su-2006
Title: Evolution of alternative splicing after gene duplication
Journal: GENOME RES, 16 (2): 182-189 FEB 2006
Citations: 5
Authors: Su, ZX;Wa, JM;Yu, J;Huang, XQ;Gu, X
Addresses:
Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310008, Peoples R China
Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310008, Peoples R China
Iowa State Univ Sci & Technol, Dept Genet Dev & Cell Biol, Ames, IA 50011 USA
Iowa State Univ Sci & Technol, Dept Comp Sci, Ames, IA 50011 USA
Iowa State Univ Sci & Technol, Ctr Bioinformat & Biol Stat, Ames, IA 50011 USA
Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China


[Back to Map]     

Label: Nagasaki-2005
Title: Species-specific variation of alternative splicing and transcriptional initiation in six eukaryotes
Journal: GENE, 364: 53-62 DEC 30 2005
Citations: 4
Authors: Nagasaki, H;Arita, M;Nishizawa, T;Suwa, M;Gotoh, O
Addresses:
Natl Inst Adv Ind Sci & Technol, Computat Biol Res Ctr, Tokyo 1350064, Japan
Natl Inst Adv Ind Sci & Technol, Computat Biol Res Ctr, Tokyo 1350064, Japan
Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol, Kashiwa, Chiba 2778561, Japan
Informat & Math Sci Lab Inc, Tokyo 1710014, Japan
Kyoto Univ, Grad Sch Informat, Dept Intelligence Sci & Technol, Kyoto 6068501, Japan


[Back to Map]     

Label: Ohler-2005
Title: Recognition of unknown conserved alternatively spliced exons
Journal: PLOS COMPUT BIOL, 1 (2): 113-122 JUL 2005
Citations: 4
Authors: Ohler, U;Shomron, N;Burge, CB
Addresses:
MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA


[Back to Map]


Menu of Emerging Research Fronts
Emerging Research Fronts Commentary Menu
Return to Special Topics Main Menu
 

ESI Special Topics, October 2006
Citing URL: http://www.esi-topics.com/erf/maps/october2006-map.html

ScienceWatch.com - Tracking Trends and Perfomance in Basic Research
Go to the new ScienceWatch.com

Write to the Webmaster with questions/comments. Terms of Usage.
The Research Services Group of Thomson Scientific |
(c) 2008 The Thomson Corporation.