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ESI Special Topics, January 2004
Citing URL: http://www.esi-topics.com/fmf/2003/january04-Pomeroy-Golub.html

From •>>January 2004

Scott Pomeroy and Todd R. Golub answer a few questions about this month's fast moving front in the field of Clinical Medicine.

Field: Clinical Medicine
Article: Prediction of central nervous system embryonal tumour outcome based on gene expression
Authors: Pomeroy, SL;Tamayo, P;Gaasenbeek, M;Sturla, LM;Angelo, M;McLaughlin, ME;Kim, JYH;Goumnerova, LC;Black, PM;Lau, C;Allen, JC;Zagzag, D;Olson, JM;Curran, T;Wetmore, C;Biegel, JA;Poggio, T;Mukherjee, S;Rifkin, R;Califano, A;Stolovitzky, G;Louis, DN;Mesirov, JP;Lander, ES;Golub, TR
Journal: NATURE, 415: (6870) 436-442, JAN 24 2002
Addresses: Harvard Univ, Sch Med, Dept Neurol, Div Neurosci, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Neurol, Div Neurosci, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Neurosurg, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Childrens Hosp, Dept Med, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Pathol & Neurosurg Serv, Boston, MA 02115 USA.
MIT, Whitehead Inst MIT Ctr Genome Res, Cambridge, MA 02139 USA.
McGovern Inst, Ctr Biol & Computat Learning, AI Lab, Cambridge, MA 02139 USA.
Baylor Coll Med, Div Pediat Oncol, Houston, TX 77030 USA.
Beth Israel Med Ctr, New York, NY 10128 USA.
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA.
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA.
St Jude Childrens Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA.
Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Div Human Genet, Philadelphia, PA 19104 USA.
MIT, Dept Biol, Cambridge, MA 02139 USA.
IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA.


ST:  Why do you think your paper is highly cited?

The work described in this paper demonstrates that DNA microarray gene expression profiles can discover cancer subclasses that cannot be detected by traditional histological techniques. Molecular markers identified by expression profiling can be used to predict tumor outcome more accurately than clinical criteria currently in use.

ST:  Does it describe a new discovery or new methodology that's useful to others?

The supervised and unsupervised methods described in the paper are generally applicable for the analysis of large datasets generated by microarray expression profiling and other genomic approaches to biologic questions.

ST:  Could you summarize the significance of your paper in layman's terms?

The results presented in this paper demonstrate that molecular markers significantly improve our ability to identify good- and poor-risk childhood brain cancer at the time of initial diagnosis, enabling clinicians to treat poor-risk patients more aggressively to improve survival and to treat good-risk patients with reduced doses of therapies that have the potential to permanently injure the developing nervous system.

ST:  How did you become involved in this research?

We have been interested in the molecular basis of cancer for over a decade.End

Scott L. Pomeroy, M.D., Ph.D.
Associate Professor of Neurology
Harvard University, School of Medicine
Department of Neurology, Division of Neuroscience
Boston, MA, USA

Todd R. Golub, M.D., Ph.D.
Charles A. Dana Investigator in Human Cancer Genetics
Associate Professor of Pediatrics
Harvard University, School of Medicine
Boston, MA, USA

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ESI Special Topics, January 2004
Citing URL: http://www.esi-topics.com/fmf/2003/january04-Pomeroy-Golub.html
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