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ESI Special Topics, July 2004
Citing URL: http://www.esi-topics.com/fmf/2004/july04-FredericBushman.html

From •>>July 2004

Frederic Bushman answers a few questions about this month's fast moving front in the field of Molecular Biology & Genetics.

Field: Molecular Biology & Genetics
Article: HIV-1 integration in the human genome favors active genes and local hotspots
 Authors: Schroder, ARW;Shinn, P;Chen, HM;Berry, C;Ecker, JR;Bushman, F
Journal: CELL, 110: (4) 521-529, AUG 23 2002
Addresses: Salk Inst Biol Studies, Infect Dis Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.
Salk Inst Biol Studies, Infect Dis Lab, La Jolla, CA 92037 USA.
Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA.
Univ Calif San Diego, Sch Med, Dept Family Prevent Med, La Jolla, CA 92093 USA.


ST:  Why do you think your paper is highly cited?

This was the first genome-wide study of HIV integration sites and it yielded a surprising answer: HIV integration was favored in active genes.

ST:  Does it describe a new discovery or new methodology that's useful to others?

HIV integrates in active genes was the discovery. The approach of using high-throughput sequencing combined with transcriptional profiling has since been used by several other groups.

ST:  Could you summarize the significance of your paper in layman's terms?

HIV does not integrate randomly into the human chromosomes but favors active genes.

ST:  How did you become involved in this research?

I have studied HIV for close to 15 years, with an emphasis on the integration phase of the viral life cycle.End

Frederick D. Bushman
Professor
Department of Microbiology
University of Pennsylvania School of Medicine
Philadelphia, PA, USA

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ESI Special Topics, July 2004
Citing URL: http://www.esi-topics.com/fmf/2004/july04-FredericBushman.html
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