***Article 1
Total Cites: 240
Article Title: A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Authors: Berns, K, Hijmans, EM, Mullenders, J, Brummelkamp, TR, Velds, A, Heimerikx, M, Kerkhoven, RM, Madiredjo, M, Nijkamp, W, Weigelt, B, Agami, R, Ge, W, Cavet, G, Linsley, PS, Beijersbergen, RL, Bernards, R
Journal: NATURE
Volume: 428
Page: 431-437
Year: 2004
Addresses: 
· Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands
· Netherlands Canc Inst, Ctr Biomed Genet, Amsterdam, Netherlands
· Netherlands Canc Inst, Div Expt Therapy, Amsterdam, Netherlands
· Netherlands Canc Inst, Div Tumor Biol, Amsterdam, Netherlands
· Rosetta Inpharmat Inc, Kirkland, WA, USA

***Article 2
Total Cites: 238
Article Title: Rational siRNA design for RNA interference
Authors: Reynolds, A, Leake, D, Boese, Q, Scaringe, S, Marshall, WS, Khvorova, A
Journal: NATURE BIOTECHNOLOGY
Volume: 22
Page: 326-330
Year: 2004
Addresses: 
· Dharmacon Inc, Lafayette, CO, USA

***Article 3
Total Cites: 220
Article Title: Mechanisms of gene silencing by double-stranded RNA
Authors: Meister, G, Tuschl, T
Journal: NATURE
Volume: 431
Page: 343-349
Year: 2004
Addresses: 
· Rockefeller Univ, Lab RNA Mol Biol, New York, NY, USA

***Article 4
Total Cites: 208
Article Title: RNAi-mediated targeting of heterochromatin by the RITS complex
Authors: Verdel, A, Jia, ST, Gerber, S, Sugiyama, T, Gygi, S, Grewal, SIS, Moazed, D
Journal: SCIENCE
Volume: 303
Page: 672-676
Year: 2004
Addresses: 
· NCI, Mol Cell Biol Lab, NIH, Bethesda, MD, USA
· Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA, USA
· Harvard Univ, Sch Med, Taplin Biol Mass Spectrometry Facil, Boston, MA, USA

***Article 5
Total Cites: 196
Article Title: Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Authors: Soutschek, J, Akinc, A, Bramlage, B, Charisse, K, Constien, R, Donoghue, M, Elbashir, S, Geick, A, Hadwiger, P, Harborth, J, John, M, Kesavan, V, Lavine, G, Pandey, RK, Racie, T, Rajeev, KG, Rohl, I, Toudjarska, I, Wang, G, Wuschko, S, Bumcrot, D, Koteliansky, V, Limmer, S, Manoharan, M, Vornlocher, HP
Journal: NATURE
Volume: 432
Page: 173-178
Year: 2004
Addresses: 
· Alnylam Europe AG, Kulmbach, Germany
· Alnylam Pharmaceut Inc, Cambridge, MA, USA

***Article 6
Total Cites: 191
Article Title: Unlocking the potential of the human genome with RNA interference
Authors: Hannon, GJ, Rossi, JJ
Journal: NATURE
Volume: 431
Page: 371-378
Year: 2004
Addresses: 
· Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY, USA
· Grad Sch Biol Sci, Beckman Res Inst City Hope, Div Mol Biol, Duarte, CA, USA

***Article 7
Total Cites: 190
Article Title: A resource for large-scale RNA-interference-based screens in mammals
Authors: Paddison, PJ, Silva, JM, Conklin, DS, Schlabach, M, Li, MM, Aruleba, S, Balija, V, Oshaughnessy, A, Gnoj, L, Scobie, K, Chang, K, Westbrook, T, Cleary, M, Sachidanandam, R, Mccombie, WR, Elledge, SJ, Hannon, GJ
Journal: NATURE
Volume: 428
Page: 427-431
Year: 2004
Addresses: 
· Watson Sch Biol Sci, Cold Spring Harbor Lab, Cold Spring Harbor, NY, USA
· Baylor Coll Med, Howard Hughes Med Inst, Dept Biochem, Houston, TX, USA
· Rosetta Inpharmat, Kirkland, WA, USA

***Article 8
Total Cites: 188
Article Title: Argonaute2 is the catalytic engine of mammalian RNAi
Authors: Liu, JD, Carmell, MA, Rivas, FV, Marsden, CG, Thomson, JM, Song, JJ, Hammond, SM, Joshua-tor, L, Hannon, GJ
Journal: SCIENCE
Volume: 305
Page: 1437-1441
Year: 2004
Addresses: 
· Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY, USA
· SUNY Stony Brook, Genet Program, Stony Brook, NY, USA
· Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC, USA

***Article 9

with

Griffiths-Jones, S
Total Cites: 170
Article Title: The microRNA Registry
Authors: Griffiths-Jones, S
Journal: NUCLEIC ACIDS RES
Volume: 32
Page: D109-D111
Year: 2004
Addresses: 
· Wellcome Trust Sanger Inst, Cambridge, England

***Article 10
Total Cites: 165
Article Title: Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
Authors: Shi, YJ, Lan, F, Matson, C, Mulligan, P, Whetstine, JR, Cole, PA, Casero, RA, Shi, Y
Journal: CELL
Volume: 119
Page: 941-953
Year: 2004
Addresses: 
· Harvard Univ, Sch Med, Dept Pathol, Boston, MA, USA
· Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD, USA
· Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD, USA

***Article 11

with

Bhadra, U
Total Cites: 155
Article Title: Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery
Authors: Pal-bhadra, M, Leibovitch, BA, Gandhi, SG, Rao, M, Bhadra, U, Birchler, JA, Elgin, SCR
Journal: SCIENCE
Volume: 303
Page: 669-672
Year: 2004
Addresses: 
· Univ Missouri, Div Biol Sci, Columbia, MO, USA
· Washington Univ, Dept Biol, St Louis, MO, USA
· Ctr Cellular & Mol Biol, Funct Genom & Gene Silencing Grp, Hyderabad, India

***Article 12
Total Cites: 153
Article Title: Nuclear export of microRNA precursors
Authors: Lund, E, Guttinger, S, Calado, A, Dahlberg, JE, Kutay, U
Journal: SCIENCE
Volume: 303
Page: 95-98
Year: 2004
Addresses: 
· Univ Wisconsin, Sch Med, Dept Biomol Chem, Madison, WI, USA
· Swiss Fed Inst Technol, Inst Biochem, Zurich, Switzerland

***Article 13
Total Cites: 147
Article Title: Small interfering RNA-induced transcriptional gene silencing in human cells
Authors: Morris, KV, Chan, SWL, Jacobsen, SE, Looney, DJ
Journal: SCIENCE
Volume: 305
Page: 1289-1292
Year: 2004
Addresses: 
· Univ Calif San Diego, Dept Med, La Jolla, CA, USA
· Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA, USA
· Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA, USA
· VA San Diego Healthcare Syst, Infect Dis, San Diego, CA, USA
· Beckman Res Inst, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA, USA

***Article 14
Total Cites: 146
Article Title: Crystal structure of argonaute and its implications for RISC slicer activity
Authors: Song, JJ, Smith, SK, Hannon, GJ, Joshua-tor, L
Journal: SCIENCE
Volume: 305
Page: 1434-1437
Year: 2004
Addresses: 
· Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY, USA
· Cold Spring Harbor Lab, Keck Struct Biol Lab, Cold Spring Harbor, NY, USA

***Article 15
Total Cites: 142
Article Title: Genome-wide RNAi analysis of growth and viability in Drosophila cells
Authors: Boutros, M, Kiger, AA, Armknecht, S, Kerr, K, Hild, M, Koch, B, Haas, SA, Paro, R, Perrimon, N, Heidelberg Fly Array Consortium
Journal: SCIENCE
Volume: 303
Page: 832-835
Year: 2004
Addresses: 
· Harvard Univ, Sch Med, Dept Genet, Boston, MA, USA
· Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA, USA
· Univ Heidelberg, Zentrum Mol Biol, Heidelberg, Germany
· Max Planck Inst Mol Genet, Berlin, Germany

***Article 16
Total Cites: 138
Article Title: Role of transposable elements in heterochromatin and epigenetic control
Authors: Lippman, Z, Gendrel, AV, Black, M, Vaughn, MW, Dedhia, N, Mccombie, WR, Lavine, K, Mittal, V, May, B, Kasschau, KD, Carrington, JC, Doerge, RW, Colot, V, Martienssen, R
Journal: NATURE
Volume: 430
Page: 471-476
Year: 2004
Addresses: 
· Watson Sch Biol Sci, Cold Spring Harbor, NY, USA
· Cold Spring Harbor Lab, Cold Spring Harbor, NY, USA
· UEVE, CNRS, INRA, Unite Rech Genom Vegetale, Evry, France
· Purdue Univ, Dept Stat, W Lafayette, IN, USA
· Oregon State Univ, Ctr Gene Res & Biotechnol, Corvallis, OR, USA

***Article 17
Total Cites: 138
Article Title: Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
Authors: Scacheri, PC, Rozenblatt-rosen, O, Caplen, NJ, Wolfsberg, TG, Umayam, L, Lee, JC, Hughes, CM, Shanmugam, KS, Bhattacharjee, A, Meyerson, M, Collins, FS
Journal: P NATL ACAD SCI USA
Volume: 101
Page: 1892-1897
Year: 2004
Addresses: 
· NHGRI, NIH, Bethesda, MD, USA
· Agilent Technol, Andover, MA, USA
· Harvard Univ, Sch Med, Dept Pathol, Boston, MA, USA
· Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA, USA

***Article 18
Total Cites: 130
Article Title: siRNAs: Applications in functional genomics and potential as therapeutics
Authors: Dorsett, Y, Tuschl, T
Journal: NATURE REVIEWS DRUG DISCOVERY
Volume: 3
Page: 318-329
Year: 2004
Addresses: 
· Rockefeller Univ, Lab RNA Mol Biol, New York, NY, USA

***Article 19
Total Cites: 123
Article Title: Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
Authors: Persengiev, SP, Zhu, XC, Green, MR
Journal: RNA-A PUBLICATION OF THE RNA SOCIETY
Volume: 10
Page: 39069
Year: 2004
Addresses: 
· Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Programs Gene Funct & Express, Worcester, MA, USA
· Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Mol Med, Worcester, MA, USA

***Article 20
Total Cites: 121
Article Title: The RNAi revolution
Authors: Novina, CD, Sharp, PA
Journal: NATURE
Volume: 430
Page: 161-164
Year: 2004
Addresses: 
· MIT, Ctr Canc Res, Cambridge, MA, USA
· MIT, Dept Biol, Cambridge, MA, USA
· MIT, McGovern Inst, Cambridge, MA, USA