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David A. Hafler answers a few questions about this month's
new hot paper in the field of Clinical Medicine.
From
•>>September 2005
Field:
Clinical Medicine
Article Title: Loss of functional suppression by CD4(+)CD25(+) regulatory T cells in patients with multiple sclerosis
Authors: Viglietta, V;Baecher-Allan, C;Weiner, HL;Hafler, DA
Journal: J EXP MED
Volume: 199
Page: 971-979
Year: APR 5 2004
* Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Mol Immunol, Ctr Neurol Dis, 77 Ave Louis Pasteur, Boston, MA 02115 USA.
* Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Mol Immunol, Ctr Neurol Dis, Boston, MA 02115 USA.
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 Why
do you think your paper is highly cited?
The recently identified regulatory T cells in mice have been
shown to be critical for the induction of experimental models of
autoimmune disease. This work represents the first description of
the loss of regulatory T cells in a human autoimmune disease.
Does
it describe a new discovery or a new methodology that's useful to
others?
It describes a new discovery that is a potential explanation for
the loss of immune regulation in patients with multiple sclerosis
(MS).
Could
you summarize the significance of your paper in layman's terms?
Patients with autoimmune diseases have a defect in immune
regulation. This observation may in part explain the underlying
cause of MS.
How
did you become involved in this research?
Our lab, the Laboratory of Molecular Immunology at the Center for
Neurologic Disease of Brigham and Women's Hospital, studies the
pathophysiology of MS.
David A. Hafler, M.D.
Jack, Sadie, and David Breakstone Professor of Neurology
Harvard Medical School
Brigham and Women's Hospital
Boston, MA, USA
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ESI Special Topics,
September 2005
Citing URL - http://www.esi-topics.com/nhp/2005/september-05-DavidAHafler.html
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