| The baseline time span for this database
is 1996-October 31, 2006. The resulting database contained 6,177 (10 years)
and 1,828 (2 years) papers; 18,892 authors; 63 countries; 745 journals; and
3,486 institutions. Read the methodology used to create this
special topic.
According to the National Cancer Institute, more than 29,000
patients are diagnosed with pancreatic cancer annually, and pancreatic
cancer is the fifth leading cause of cancer deaths in the United
States. This month, Special Topics examines pancreatic cancer research
over the past decade and over the past two years.
The most-cited papers of the past decade focus on pancreatic cancer
genetics, as showcased in the #1 paper, "DPC4, a candidate tumor
suppressor gene at human chromosome 18q21.1" (Hahn SA et al.,
Science 271[5247]: 350-3, 19 January 1996). Dr.
Scott Kern talks about this paper and its importance to the field
in his interview here. Other topics highly cited in the past 10 years
include TGF-beta signaling pathways, cyclooxygenase-2 expression,
epidermal growth factor receptor signaling, BRCA2 gene mutations, the
risk conveyed by hereditary pancreatitis, the potential of NSAIDS as
chemoprevention, and the results of trials examining curative
resection and therapy with gemcitabine.
The two-year data appears to focus much more on treatment options,
with papers detailing trial results using cetuximab plus gemcitabine,
tipifamib plus gemcitabine, oxaliplatin plus gemcitabine, irinotecan
plus gemcitabine, and CI-1040. Other topics garnering citation
attention over the past two years include serum diagnosis of
pancreatic cancer, studies determining patient outcome and survival,
high-resolution characterization of the pancreatic cancer genome,
CEACAM6 gene silencing,
genomic DNA chip hybridization, and the effects of radiation to
stromal fibroblasts on cancer cell invasiveness.
Methodology
To construct this database,
papers were extracted based on title-supplied keywords for
Pancreatic Cancer. The keywords used were as follows:
"pancreatic cancer*" OR pancrea* AND neoplasm OR pancrea* AND tumor OR pancrea* AND cancer OR pancrea* AND carcinoma* OR pancrea* AND adenocarcinoma* OR pancreatic ductal adenocarcinoma* OR pancreatobiliary carcinoma OR pancrea* AND biliary cancer* OR pancreatic intraepithelial neoplas* OR pancrea* AND malignan* OR DPC*
The baseline time span for this database
is 1996-October 31, 2006. The resulting database contained 6,177 (10 years)
and 1,828 (2 years) papers; 18,892 authors; 63 countries; 745 journals; and
3,486 institutions.
Rankings
Once the database was in place,
it was used to generate the lists of top 20 papers (two- and ten-year
periods), authors, journals,
institutions, and nations, covering a time span of 1996-October 31,
2006 (fifth bimonthly, a 10-year plus 10-month period).
The top 20 papers are ranked
according to total cites. Rankings for author, journal, institution,
and country are listed in three ways: according to total cites, total
papers, and total cites/paper. The paper thresholds and corresponding
percentages used to determine
scientist, institution, country, and journal rankings according to
total cites/paper, and total papers respectively are as follows:
| Entity: |
Scientists |
Institutions |
Countries |
Journals |
| Thresholds: |
16 |
46 |
10 |
20 |
| Percentage: |
1% |
1% |
50% |
10% |
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