***Article 1
Total Cites: 1255
Article Title: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
Authors: Hahn, SA, Schutte, M, Hoque, ATMS, Moskaluk, CA, dacosta, LT, Rozenblum, E, Weinstein, CL, Fischer, A, Yeo, CJ, Hruban, RH, Kern, SE
Journal: SCIENCE
Volume: 271
Page: 350-353
Year: 1996
Addresses: 
· JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD, USA
· JOHNS HOPKINS UNIV, SCH MED, DEPT SURG, BALTIMORE, MD, USA
· JOHNS HOPKINS UNIV, SCH MED, GRAD PROGRAM HUMAN GENET & MOLEC BIOL, BALTIMORE, MD, USA

***Article 2
Total Cites: 850
Article Title: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
Authors: Burris, HA, Moore, MJ, Andersen, J, Green, MR, Rothenberg, ML, Madiano, MR, Cripps, MC, Portenoy, RK, Storniolo, AM, Tarassoff, P, Nelson, R, Dorr, FA, Stephens, CD, Vanhoff, DD
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 15
Page: 2403-2413
Year: 1997
Addresses: 
· INST DRUG DEV, CANC THERAPY & RES CTR, SAN ANTONIO, TX, USA
· USA, BROOKE MED CTR, FT SAM HOUSTON, TX, USA
· UNIV TEXAS, HLTH SCI CTR, SAN ANTONIO, TX, USA
· PRINCESS MARGARET HOSP, TORONTO, CANADA
· ONTARIO CANC TREATMENT & RES FDN, OTTAWA, CANADA
· ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, IN, USA
· UNIV CALIF SAN DIEGO, CTR CANC, SAN DIEGO, CA, USA
· ARIZONA CLIN RES CTR, TUCSON, AZ, USA
· CANC CARE CTR SO ARIZONA, TUCSON, AZ, USA
· MEM SLOAN KETTERING CANC CTR, NEW YORK, NY, USA

***Article 3
Total Cites: 574
Article Title: Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
Authors: Lagna, G, Hata, A, Hemmatibrivanlou, A, Massague, J
Journal: NATURE
Volume: 383
Page: 832-836
Year: 1996
Addresses: 
· MEM SLOAN KETTERING CANC CTR, NEW YORK, NY, USA
· ROCKEFELLER UNIV, HOWARD HUGHES MED INST, MOL EMBRYOL LAB, NEW YORK, NY, USA

***Article 4
Total Cites: 438
Article Title: DPC4 gene in various tumor types
Authors: Schutte, M, Hruban, RH, Hedrick, L, Cho, KR, Nadasdy, GM, Weinstein, CL, Bova, GS, Isaacs, WB, Cairns, P, Nawroz, H, Sidransky, D, Casero, RA, Meltzer, PS, Hahn, SA, Kern, SE
Journal: CANCER RESEARCH
Volume: 56
Page: 2527-2530
Year: 1996
Addresses: 
· JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT UROL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT OTOLARYNGOL, BALTIMORE, MD, USA
· NIH, NATL CTR HUMAN GENOME RES, CANC GENET LAB, BETHESDA, MD, USA

***Article 5
Total Cites: 345
Article Title: Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
Authors: Tucker, ON, Dannenberg, AJ, Yang, FK, Zhang, F, Teng, LS, Daly, JM, Soslow, RA, Masferrer, JL, Woerner, BM, Koki, AT, Fahey, TJ
Journal: CANCER RESEARCH
Volume: 59
Page: 987-990
Year: 1999
Addresses: 
· Cornell Univ, New York Presbyterian Hosp, Dept Surg, New York, NY, USA
· Cornell Univ, New York Presbyterian Hosp, Dept Med, New York, NY, USA
· Cornell Univ, New York Presbyterian Hosp, Dept Pathol, New York, NY, USA
· Cornell Univ, Weill Med Coll, New York, NY, USA
· Strang Canc Prevent Ctr, New York, NY, USA
· Monsanto Co, Searle Discovery Res, St Louis, MO, USA
· Cornell Univ, New York Presbyterian Hosp, Dept Surg, Room F-2024,525 E 68th St, New York, NY, USA

***Article 6
Total Cites: 337
Article Title: Amplification of AKT2 in human pancreatic cancer cells and inhibition of ATK2 expression and tumorigenicity by antisense RNA
Authors: Cheng, JQ, Ruggeri, B, Klein, WM, Sonoda, G, Altomare, DA, Watson, DK, Testa, JR
Journal: P NATL ACAD SCI USA
Volume: 93
Page: 3636-3641
Year: 1996
Addresses: 
· FOX CHASE CANC CTR, DEPT MED ONCOL, PHILADELPHIA, PA, USA
· MED COLL PENN & HAHNEMANN UNIV, DEPT PATHOL, PHILADELPHIA, PA, USA
· MED UNIV S CAROLINA, HOLLINGS CANC CTR, CTR MOL & STRUCT BIOL, CHARLESTON, SC, USA

***Article 7
Total Cites: 307
Article Title: Mutations in the SMAD4/DPC4 gene in juvenile polyposis
Authors: Howe, JR, Roth, S, Ringold, JC, Summers, RW, Jarvinen, HJ, Sistonen, P, Tomlinson, IPM, Houlston, RS, Bevan, S, Mitros, FA, Stone, EM, Aaltonen, LA
Journal: SCIENCE
Volume: 280
Page: 1086-1088
Year: 1998
Addresses: 
· Univ Iowa, Coll Med, Dept Surg, Iowa City, IA, USA
· Univ Helsinki, Haartman Inst, Dept Med Genet, Helsinki, Finland
· Univ Iowa, Coll Med, Dept Med, Iowa City, IA, USA
· Univ Helsinki, Cent Hosp, Dept Surg 2, Helsinki, Finland
· Finnish Red Cross & Blood Transfus Serv, Helsinki, Finland
· Imperial Canc Res Fund, Mol Populat Genet Lab, London, England
· Inst Canc Res, Sect Can Genet, Surrey, England
· Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA, USA
· Univ Iowa, Coll Med, Dept Ophthalmol, Iowa City, IA, USA

***Article 8
Total Cites: 300
Article Title: A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
Authors: Rothenberg, ML, Moore, MJ, Cripps, MC, Andersen, JS, Portenoy, RK, Burris, HA, Green, MR, Tarassoff, PG, Brown, TD, Casper, ES, Storniolo, AM, Vonhoff, DD, Alberts, DS, Wolff, R, Kelsen, DP, Kocha, W, Haller, DG, Modianorevah, M, Moore, M, Oken, MM, Schilsky, RL, Shah, A
Journal: ANNALS OF ONCOLOGY
Volume: 7
Page: 347-353
Year: 1996
Addresses: 
· CANC THERAPY & RES CTR S TEXAS, SAN ANTONIO, TX, USA
· PRINCESS MARGARET HOSP, TORONTO, CANADA
· OTTAWA REG CANC CTR, OTTAWA, CANADA
· ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, IN, USA
· MEM SLOAN KETTERING CANC CTR, NEW YORK, NY, USA
· BROOKE ARMY MED CTR, FT SAM HOUSTON, TX, USA
· UNIV CALIF SAN DIEGO, CTR CANC, SAN DIEGO, CA, USA
· DUKE UNIV, MED CTR, DURHAM, NC, USA
· UNIV TEXAS, HLTH SCI CTR, DIV MED ONCOL, 7703 FLOYD CURL DR, SAN ANTONIO, TX, USA

***Article 9
Total Cites: 295
Article Title: The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta-induced transcriptional activation
Authors: Feng, XH, Zhang, Y, Wu, RY, Derynck, R
Journal: GENE DEV
Volume: 12
Page: 2153-2163
Year: 1998
Addresses: 
· Univ Calif San Francisco, Dept Growth & Dev, San Francisco, CA, USA
· Univ Calif San Francisco, Dept Anat, San Francisco, CA, USA
· Univ Calif San Francisco, Cell Biol Program, San Francisco, CA, USA
· Univ Calif San Francisco, Program Dev Biol, San Francisco, CA, USA

***Article 10
Total Cites: 270
Article Title: Dual role of the Smad4/DPC4 tumor suppressor in TGF beta-inducible transcriptional complexes
Authors: Liu, F, Pouponnot, C, Massague, J
Journal: GENE DEV
Volume: 11
Page: 3157-3167
Year: 1997
Addresses: 
· MEM SLOAN KETTERING CANC CTR, CELL BIOL PROGRAM, NEW YORK, NY, USA
· MEM SLOAN KETTERING CANC CTR, HOWARD HUGHES MED INST, NEW YORK, NY, USA

***Article 11
Total Cites: 254
Article Title: Tumor-suppressive pathways in pancreatic carcinoma
Authors: Rozenblum, E, Schutte, M, Goggins, M, Hahn, SA, Panzer, S, Zahurak, M, Goodman, SN, Sohn, TA, Hruban, RH, Yeo, CJ, Kern, SE
Journal: CANCER RESEARCH
Volume: 57
Page: 1731-1734
Year: 1997
Addresses: 
· JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT GASTROENTEROL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, MD, USA

***Article 12
Total Cites: 240
Article Title: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
Authors: Bruns, CJ, Solorzano, CC, Harbison, MT, Ozawa, S, Tsan, R, Fan, D, Abbruzzese, J, Traxler, P, Buchdunger, E, Radinsky, R, Fidler, IJ
Journal: CANCER RESEARCH
Volume: 60
Page: 2926-2935
Year: 2000
Addresses: 
· Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX, USA
· Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Oncol & Digest Dis, Houston, TX, USA
· Novartis Pharma, Basel, Switzerland
· Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Box 173,1515 Holcombe Blvd, Houston, TX, USA

***Article 13
Total Cites: 237
Article Title: Hereditary pancreatitis and the risk of pancreatic cancer
Authors: Lowenfels, AB, Maisonneuve, P, Dimagno, EP, Elitsur, Y, Gates, LK, Perrault, J, Whitcomb, DC, Aranha, G, Banks, P, Burton, FR, Carrlocke, D, Dyck, WP, Gish, RG, Goodale, RL, Lehman, G, Martin, SP, Potts, J, Sherman, S, Ulrich, CD, Yakshe, P, Yeaton, P, Hamanaka, Y, Koizumi, M, Tomioka, T, Tsunoda, T, Yamadera, K, Delmont, JP, Beger, HG, Holstege, A, Keim, V, Layer, P, Triantafillidis, J, Boyle, P, Cavallini, G, Gullo, L, Pedrazzoli, S, Uomo, G, Castano, DGL, Ihse, I, Buchler, M, Elias, E
Journal: J NATL CANCER I
Volume: 89
Page: 442-446
Year: 1997
Addresses: 
· NEW YORK MED COLL, DEPT COMMUNITY & PREVENT MED, VALHALLA, NY, USA
· MAYO CLIN & MAYO GRAD SCH MED, GASTROINTESTINAL RES UNIT, ROCHESTER, MN, USA
· MARSHALL UNIV, SCH MED, PEDIAT GASTROENTEROL DIV, HUNTINGTON, WV, USA
· UNIV KENTUCKY, MED CTR, LEXINGTON, KY, USA
· LEXINGTON VET AFFAIRS MED CTR, LEXINGTON, KY, USA
· PITTSBURGH VET AFFAIRS MED CTR, GASTROENTEROL & HEPATOL SECT, PITTSBURGH, PA, USA
· EUROPEAN INST ONCOL, DIV EPIDEMIOL & BIOSTAT, MILAN, ITALY
· NEW YORK MED COLL, DEPT SURG, VALHALLA, NY, USA

***Article 14
Total Cites: 236
Article Title: Pancreaticoduodenectomy for pancreatic adenocarcinoma: Postoperative adjuvant chemoradiation improves survival - A prospective, single-institution experience
Authors: Yeo, CJ, Abrams, RA, Grochow, LB, Sohn, TA, Ord, SE, Hruban, RH, Zahurak, ML, Dooley, WC, Coleman, J, Sauter, PK, Pitt, HA, Lillemoe, KD, Cameron, JL
Journal: ANNALS OF SURGERY
Volume: 225
Page: 621-633
Year: 1997
Addresses: 
· JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, MD, USA

***Article 15
Total Cites: 219
Article Title: Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
Authors: Takaku, K, Oshima, M, Miyoshi, H, Matsui, M, Seldin, MF, Taketo, MM
Journal: CELL
Volume: 92
Page: 645-656
Year: 1998
Addresses: 
· Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Tokyo, Japan
· Banyu Tsukuba Res Inst Merck, Tsukuba, Japan
· Univ Calif Davis, Dept Biol Chem, Rowe Program Genet, Davis, CA, USA

***Article 16
Total Cites: 216
Article Title: Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
Authors: Goggins, M, Schutte, M, Lu, J, Moskaluk, CA, Weinstein, CL, Petersen, GM, Yeo, CJ, Jackson, CE, Lynch, HT, Hruban, RH, Kern, SE
Journal: CANCER RESEARCH
Volume: 56
Page: 5360-5364
Year: 1996
Addresses: 
· JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT CELLULAR & MOL MED, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PUBL HLTH, BALTIMORE, MD, USA
· HENRY FORD HOSP, DEPT MED, DIV CLIN & MOL GENET, DETROIT, MI, USA
· CREIGHTON UNIV, SCH MED, DEPT PREVENT MED PUBL HLTH, OMAHA, NE, USA

***Article 17
Total Cites: 215
Article Title: Long-term survival after curative resection for pancreatic ductal adenocarcinoma - Clinicopathologic analysis of 5-year survivors
Authors: Conlon, KC, Klimstra, DS, Brennan, MF
Journal: ANNALS OF SURGERY
Volume: 223
Page: 273-279
Year: 1996
Addresses: 
· MEM SLOAN KETTERING CANC CTR, DEPT SURG, NEW YORK, NY, USA
· MEM SLOAN KETTERING CANC CTR, DEPT PATHOL, NEW YORK, NY, USA

***Article 18
Total Cites: 209
Article Title: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
Authors: Schutte, M, Hruban, RH, Geradts, J, Maynard, R, Hilgers, W, Rabindran, SK, Moskaluk, CA, Hahn, SA, Schwartewaldhoff, I, Schmiegel, W, Baylin, SB, Kern, SE, Herman, JG
Journal: CANCER RESEARCH
Volume: 57
Page: 3126-3130
Year: 1997
Addresses: 
· JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, MD, USA
· JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, MD, USA
· UNIV N CAROLINA, SCH MED, DEPT PATHOL & LAB MED, CHAPEL HILL, NC, USA
· WYETH AYERST RES, ONCOL IMMUNOL RES, PEARL RIVER, NY, USA
· RUHR UNIV BOCHUM, MED CLIN IMBL, BOCHUM, GERMANY

***Article 19
Total Cites: 207
Article Title: The tumor suppressor Smad4 DPC 4 as a central mediator of Smad function
Authors: Zhang, Y, Musci, T, Derynck, R
Journal: CURRENT BIOLOGY
Volume: 7
Page: 270-276
Year: 1997
Addresses: 
· UNIV CALIF SAN FRANCISCO, DEPT GROWTH & DEV, SAN FRANCISCO, CA, USA
· UNIV CALIF SAN FRANCISCO, DEPT ANAT, SAN FRANCISCO, CA, USA
· UNIV CALIF SAN FRANCISCO, DEPT OBSTET & GYNECOL, CELL BIOL PROGRAM, SAN FRANCISCO, CA, USA
· UNIV CALIF SAN FRANCISCO, DEPT OBSTET & GYNECOL, PROGRAM DEV BIOL, SAN FRANCISCO, CA, USA

***Article 20
Total Cites: 198
Article Title: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
Authors: Molina, MA, Sitja-arnau, M, Lemoine, MG, Frazier, ML, Sinicrope, FA
Journal: CANCER RESEARCH
Volume: 59
Page: 4356-4362
Year: 1999
Addresses: 
· Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol & Digest Dis, Houston, TX, USA
· Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX, USA
· Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol & Digest Dis, 1515 Holcombe Blvd,Box 78, Houston, TX, USA