Pancreatic Cancer

Label: Hahn-1996
Title: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
Journal: SCIENCE, vol. 271, p. 350-353, 1996
Citations: 1255
Authors: Hahn, SA; Schutte, M; Hoque, ATMS; Moskaluk, CA; daCosta, LT; Rozenblum, E; Weinstein, CL; Fischer, A; Yeo, CJ; Hruban, RH; Kern, SE
Addresses:
JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, USA
JOHNS HOPKINS UNIV, SCH MED, DEPT SURG, BALTIMORE, USA
JOHNS HOPKINS UNIV, SCH MED, GRAD PROGRAM HUMAN GENET & MOLEC BIOL, BALTIMORE, USA

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Label: Burris-1997
Title: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
Journal: J CLIN ONCOL, vol. 15, p. 2403-2413, 1997
Citations: 850
Authors: Burris, HA; Moore, MJ; Andersen, J; Green, MR; Rothenberg, ML; Madiano, MR; Cripps, MC; Portenoy, RK; Storniolo, AM; Tarassoff, P; Nelson, R; Dorr, FA; Stephens, CD; VanHoff, DD
Addresses:
INST DRUG DEV, CANC THERAPY & RES CTR, SAN ANTONIO, USA
USA, BROOKE MED CTR, FT SAM HOUSTON, USA
UNIV TEXAS, HLTH SCI CTR, SAN ANTONIO, USA
PRINCESS MARGARET HOSP, , TORONTO, CANADA
ONTARIO CANC TREATMENT & RES FDN, , OTTAWA, CANADA
ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, USA
UNIV CALIF SAN DIEGO, CTR CANC, SAN DIEGO, USA
ARIZONA CLIN RES CTR, , TUCSON, USA
CANC CARE CTR SO ARIZONA, , TUCSON, USA
MEM SLOAN KETTERING CANC CTR, , NEW YORK, USA

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Label: Lagna-1996
Title: Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
Journal: NATURE, vol. 383, p. 832-836, 1996
Citations: 574
Authors: Lagna, G; Hata, A; HemmatiBrivanlou, A; Massague, J
Addresses:
MEM SLOAN KETTERING CANC CTR, , NEW YORK, USA
ROCKEFELLER UNIV, HOWARD HUGHES MED INST, MOL EMBRYOL LAB, NEW YORK, USA

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Label: Schutte-1996
Title: DPC4 gene in various tumor types
Journal: CANCER RES, vol. 56, p. 2527-2530, 1996
Citations: 438
Authors: Schutte, M; Hruban, RH; Hedrick, L; Cho, KR; Nadasdy, GM; Weinstein, CL; Bova, GS; Isaacs, WB; Cairns, P; Nawroz, H; Sidransky, D; Casero, RA; Meltzer, PS; Hahn, SA; Kern, SE
Addresses:
JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT UROL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT OTOLARYNGOL, BALTIMORE, USA
NIH, NATL CTR HUMAN GENOME RES, CANC GENET LAB, BETHESDA, USA

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Label: Tucker-1999
Title: Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
Journal: CANCER RES, vol. 59, p. 987-990, 1999
Citations: 345
Authors: Tucker, ON; Dannenberg, AJ; Yang, FK; Zhang, F; Teng, LS; Daly, JM; Soslow, RA; Masferrer, JL; Woerner, BM; Koki, AT; Fahey, TJ
Addresses:
Cornell Univ, New York Presbyterian Hosp, New York, USA
Cornell Univ, New York Presbyterian Hosp, New York, USA
Cornell Univ, New York Presbyterian Hosp, New York, USA
Cornell Univ, Weill Med Coll, New York, USA
Strang Canc Prevent Ctr, , New York, USA
Monsanto Co, Searle Discovery Res, St Louis, USA
Cornell Univ, New York Presbyterian Hosp, New York, USA

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Label: Cheng-1996
Title: Amplification of AKT2 in human pancreatic cancer cells and inhibition of ATK2 expression and tumorigenicity by antisense RNA
Journal: P NATL ACAD SCI USA, vol. 93, p. 3636-3641, 1996
Citations: 337
Authors: Cheng, JQ; Ruggeri, B; Klein, WM; Sonoda, G; Altomare, DA; Watson, DK; Testa, JR
Addresses:
FOX CHASE CANC CTR, DEPT MED ONCOL, PHILADELPHIA, USA
MED COLL PENN & HAHNEMANN UNIV, DEPT PATHOL, PHILADELPHIA, USA
MED UNIV S CAROLINA, HOLLINGS CANC CTR, CTR MOL & STRUCT BIOL, CHARLESTON, USA

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Label: Howe-1998
Title: Mutations in the SMAD4/DPC4 gene in juvenile polyposis
Journal: SCIENCE, vol. 280, p. 1086-1088, 1998
Citations: 307
Authors: Howe, JR; Roth, S; Ringold, JC; Summers, RW; Jarvinen, HJ; Sistonen, P; Tomlinson, IPM; Houlston, RS; Bevan, S; Mitros, FA; Stone, EM; Aaltonen, LA
Addresses:
Univ Iowa, Coll Med, Iowa City, USA
Univ Helsinki, Haartman Inst, Helsinki, Finland
Univ Iowa, Coll Med, Iowa City, USA
Univ Helsinki, Cent Hosp, Helsinki, Finland
Finnish Red Cross & Blood Transfus Serv, , Helsinki, Finland
Imperial Canc Res Fund, Mol Populat Genet Lab, London, England
Inst Canc Res, Sect Can Genet, Surrey, England
Univ Iowa, Coll Med, Iowa City, USA
Univ Iowa, Coll Med, Iowa City, USA

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Label: Rothenberg-1996
Title: A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
Journal: ANN ONCOL, vol. 7, p. 347-353, 1996
Citations: 300
Authors: Rothenberg, ML; Moore, MJ; Cripps, MC; Andersen, JS; Portenoy, RK; Burris, HA; Green, MR; Tarassoff, PG; Brown, TD; Casper, ES; Storniolo, AM; VonHoff, DD; Alberts, DS; Wolff, R; Kelsen, DP; Kocha, W; Haller, DG; ModianoRevah, M; Moore, M; Oken, MM; Schilsky, RL; Shah, A
Addresses:
CANC THERAPY & RES CTR S TEXAS, , SAN ANTONIO, USA
PRINCESS MARGARET HOSP, , TORONTO, CANADA
OTTAWA REG CANC CTR, , OTTAWA, CANADA
ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, USA
MEM SLOAN KETTERING CANC CTR, , NEW YORK, USA
BROOKE ARMY MED CTR, , FT SAM HOUSTON, USA
UNIV CALIF SAN DIEGO, CTR CANC, SAN DIEGO, USA
DUKE UNIV, MED CTR, DURHAM, USA
UNIV TEXAS, HLTH SCI CTR, DIV MED ONCOL, 7703 FLOYD CURL DR, SAN ANTONIO, USA

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Label: Feng-1998
Title: The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta-induced transcriptional activation
Journal: GENE DEV, vol. 12, p. 2153-2163, 1998
Citations: 295
Authors: Feng, XH; Zhang, Y; Wu, RY; Derynck, R
Addresses:
Univ Calif San Francisco, Dept Growth & Dev, San Francisco, USA
Univ Calif San Francisco, Dept Anat, San Francisco, USA
Univ Calif San Francisco, Cell Biol Program, San Francisco, USA
Univ Calif San Francisco, Program Dev Biol, San Francisco, USA

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Label: Liu-1997
Title: Dual role of the Smad4/DPC4 tumor suppressor in TGF beta-inducible transcriptional complexes
Journal: GENE DEV, vol. 11, p. 3157-3167, 1997
Citations: 270
Authors: Liu, F; Pouponnot, C; Massague, J
Addresses:
MEM SLOAN KETTERING CANC CTR, CELL BIOL PROGRAM, NEW YORK, USA
MEM SLOAN KETTERING CANC CTR, HOWARD HUGHES MED INST, NEW YORK, USA

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Label: Rozenblum-1997
Title: Tumor-suppressive pathways in pancreatic carcinoma
Journal: CANCER RES, vol. 57, p. 1731-1734, 1997
Citations: 254
Authors: Rozenblum, E; Schutte, M; Goggins, M; Hahn, SA; Panzer, S; Zahurak, M; Goodman, SN; Sohn, TA; Hruban, RH; Yeo, CJ; Kern, SE
Addresses:
JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT GASTROENTEROL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, USA

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Label: Bruns-2000
Title: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
Journal: CANCER RES, vol. 60, p. 2926-2935, 2000
Citations: 240
Authors: Bruns, CJ; Solorzano, CC; Harbison, MT; Ozawa, S; Tsan, R; Fan, D; Abbruzzese, J; Traxler, P; Buchdunger, E; Radinsky, R; Fidler, IJ
Addresses:
Univ Texas, MD Anderson Canc Ctr, Houston, USA
Univ Texas, MD Anderson Canc Ctr, Houston, USA
Novartis Pharma, , Basel, Switzerland
Univ Texas, MD Anderson Canc Ctr, Houston, USA

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Label: Lowenfels-1997
Title: Hereditary pancreatitis and the risk of pancreatic cancer
Journal: J NATL CANCER I, vol. 89, p. 442-446, 1997
Citations: 237
Authors: Lowenfels, AB; Maisonneuve, P; DiMagno, EP; Elitsur, Y; Gates, LK; Perrault, J; Whitcomb, DC; Aranha, G; Banks, P; Burton, FR; CarrLocke, D; Dyck, WP; Gish, RG; Goodale, RL; Lehman, G; Martin, SP; Potts, J; Sherman, S; Ulrich, CD; Yakshe, P; Yeaton, P; Hamanaka, Y; Koizumi, M; Tomioka, T; Tsunoda, T; Yamadera, K; Delmont, JP; Beger, HG; Holstege, A; Keim, V; Layer, P; Triantafillidis, J; Boyle, P; Cavallini, G; Gullo, L; Pedrazzoli, S; Uomo, G; Castano, DGL; Ihse, I; Buchler, M; Elias, E
Addresses:
NEW YORK MED COLL, DEPT COMMUNITY & PREVENT MED, VALHALLA, USA
MAYO CLIN & MAYO GRAD SCH MED, GASTROINTESTINAL RES UNIT, ROCHESTER, USA
MARSHALL UNIV, SCH MED, PEDIAT GASTROENTEROL DIV, HUNTINGTON, USA
UNIV KENTUCKY, MED CTR, LEXINGTON, USA
LEXINGTON VET AFFAIRS MED CTR, , LEXINGTON, USA
PITTSBURGH VET AFFAIRS MED CTR, GASTROENTEROL & HEPATOL SECT, PITTSBURGH, USA
EUROPEAN INST ONCOL, DIV EPIDEMIOL & BIOSTAT, MILAN, ITALY
NEW YORK MED COLL, DEPT SURG, VALHALLA, USA

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Label: Yeo-1997
Title: Pancreaticoduodenectomy for pancreatic adenocarcinoma: Postoperative adjuvant chemoradiation improves survival - A prospective, single-institution experience
Journal: ANN SURG, vol. 225, p. 621-633, 1997
Citations: 236
Authors: Yeo, CJ; Abrams, RA; Grochow, LB; Sohn, TA; Ord, SE; Hruban, RH; Zahurak, ML; Dooley, WC; Coleman, J; Sauter, PK; Pitt, HA; Lillemoe, KD; Cameron, JL
Addresses:
JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, USA

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Label: Takaku-1998
Title: Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
Journal: CELL, vol. 92, p. 645-656, 1998
Citations: 219
Authors: Takaku, K; Oshima, M; Miyoshi, H; Matsui, M; Seldin, MF; Taketo, MM
Addresses:
Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo, Japan
Banyu Tsukuba Res Inst Merck, , Tsukuba, Japan
Univ Calif Davis, Dept Biol Chem, Davis, USA

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Label: Goggins-1996
Title: Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
Journal: CANCER RES, vol. 56, p. 5360-5364, 1996
Citations: 216
Authors: Goggins, M; Schutte, M; Lu, J; Moskaluk, CA; Weinstein, CL; Petersen, GM; Yeo, CJ; Jackson, CE; Lynch, HT; Hruban, RH; Kern, SE
Addresses:
JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT SURG, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT CELLULAR & MOL MED, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PUBL HLTH, BALTIMORE, USA
HENRY FORD HOSP, DEPT MED, DIV CLIN & MOL GENET, DETROIT, USA
CREIGHTON UNIV, SCH MED, DEPT PREVENT MED PUBL HLTH, OMAHA, USA

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Label: Conlon-1996
Title: Long-term survival after curative resection for pancreatic ductal adenocarcinoma - Clinicopathologic analysis of 5-year survivors
Journal: ANN SURG, vol. 223, p. 273-279, 1996
Citations: 215
Authors: Conlon, KC; Klimstra, DS; Brennan, MF
Addresses:
MEM SLOAN KETTERING CANC CTR, DEPT SURG, NEW YORK, USA
MEM SLOAN KETTERING CANC CTR, DEPT PATHOL, NEW YORK, USA

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Label: Schutte-1997
Title: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
Journal: CANCER RES, vol. 57, p. 3126-3130, 1997
Citations: 209
Authors: Schutte, M; Hruban, RH; Geradts, J; Maynard, R; Hilgers, W; Rabindran, SK; Moskaluk, CA; Hahn, SA; SchwarteWaldhoff, I; Schmiegel, W; Baylin, SB; Kern, SE; Herman, JG
Addresses:
JOHNS HOPKINS MED INST, DEPT ONCOL, BALTIMORE, USA
JOHNS HOPKINS MED INST, DEPT PATHOL, BALTIMORE, USA
UNIV N CAROLINA, SCH MED, DEPT PATHOL & LAB MED, CHAPEL HILL, USA
WYETH AYERST RES, ONCOL IMMUNOL RES, PEARL RIVER, USA
RUHR UNIV BOCHUM, MED CLIN IMBL, BOCHUM, GERMANY

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Label: Zhang-1997
Title: The tumor suppressor Smad4 DPC 4 as a central mediator of Smad function
Journal: CURR BIOL, vol. 7, p. 270-276, 1997
Citations: 207
Authors: Zhang, Y; Musci, T; Derynck, R
Addresses:
UNIV CALIF SAN FRANCISCO, DEPT GROWTH & DEV, SAN FRANCISCO, USA
UNIV CALIF SAN FRANCISCO, DEPT ANAT, SAN FRANCISCO, USA
UNIV CALIF SAN FRANCISCO, DEPT OBSTET & GYNECOL, CELL BIOL PROGRAM, SAN FRANCISCO, USA
UNIV CALIF SAN FRANCISCO, DEPT OBSTET & GYNECOL, PROGRAM DEV BIOL, SAN FRANCISCO, USA

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Label: Molina-1999
Title: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
Journal: CANCER RES, vol. 59, p. 4356-4362, 1999
Citations: 198
Authors: Molina, MA; Sitja-Arnau, M; Lemoine, MG; Frazier, ML; Sinicrope, FA
Addresses:
Univ Texas, MD Anderson Canc Ctr, Houston, USA
Univ Texas, MD Anderson Canc Ctr, Houston, USA
Univ Texas, MD Anderson Canc Ctr, Houston, USA

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