According to the National Cancer Institute, prostate cancer is the
second leading cause of cancer-related deaths in the United States. In
the United Kingdom, over 30,000 new cases of prostate cancer are
diagnosed each year, says the organization Cancer Research UK. This
month, Special Topics examines prostate cancer research over the past
decade as well as over the past two years.
The papers for both time periods cover a similar range of topics
from diagnostic tools to treatments to gene studies. The use of the
prostate-specific antigen (PSA) as a diagnostic and staging tool is
prevalent across all years of the analysis.
Other studies in the 10-year data set include: the role of the
androgen receptor gene, studies examining mutations in the tumor
suppressor gene PTEN, the role of tyrosine kinase receptors, DNA
screening, and a variety of treatments, including radiation therapy,
radical prostatectomy, goserlin, Taxol (paclitaxel), and mitoxantrone
plus prednisone.
The two-year data set contains more papers on different treatment
studies compared with the 10-year data set. Treatments being studied
and cited in the past two years include: docetaxel plus prednisone vs.
prednisone alone, docetaxel plus estramustine vs. mitoxantrone plus
prednisone, atrasentran, and calcitrol plus docetaxel. There is also a
study looking at the use of zoledronic acid for prevention of bone
loss during androgen-deprivation therapy. Other notable studies
include a report from the Prostate Cancer Prevention Trial on the use
of finasteride as a preventative agent, and the development of
high-resolution MRI with magnetic nanoparticles for noninvasive
detection of prostate cancer.
Methodology
To construct this database,
papers were extracted based on title-supplied keywords for Prostate
Cancer. The keywords used were as follows:
prostate cancer
The baseline time span for this database
is 1995-2005 (fifth bimonthly). The resulting database contained 10,962 (10 years)
and 4,283 (2 years) papers; 26,695 authors; 82 countries; 841 journals; and
4,663 institutions. Read the methodology used to create this
special topic.
Rankings
Once the database was in place,
it was used to generate the lists of top 20 papers (two- and ten-year
periods), authors, journals,
institutions, and nations, covering a time span of 1995-2006 (fifth bimonthly,
a 10-year plus 10-month period).
The top 20 papers are ranked
according to total cites. Rankings for author, journal, institution,
and country are listed in three ways: according to total cites, total
papers, and total cites/paper. The paper thresholds and corresponding
percentages used to determine
scientist, institution, country, and journal rankings according to
total cites/paper, and total papers respectively are as follows:
| Entity: |
Scientists |
Institutions |
Countries |
Journals |
| Thresholds: |
56 |
109 |
8 |
21 |
| Percentage: |
1% |
5% |
50% |
10% |
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