***Article 1
Total Cites: 2994
Article Title: ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE
Authors: Folkman, J
Journal: NAT MED
Volume: 1
Page: 27-31
Year: 1995
Addresses: 
· HARVARD UNIV, SCH MED, BOSTON, MA, USA

***Article 2
Total Cites: 1149
Article Title: Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis.
Authors: Bombardier, C, Laine, L, Reicin, A, Shapiro, D, Burgos-vargas, R, Davis, B, Day, R, Ferraz, MB, Hawkey, CJ, Hochberg, MC, Kvien, TK, Schnitzer, TJ, Weaver, A, Vigor Study Grp
Journal: NEW ENGL J MED
Volume: 343
Page: 1520-1528
Year: 2000
Addresses: 
· Mt Sinai Hosp, Inst Work & Hlth, Toronto, Canada
· Univ Hlth Network, Toronto, Canada
· Univ So Calif, Sch Med, Dept Med, Gastrointestinal Div, Los Angeles, CA, USA
· Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico
· Univ Nacl Autonoma Mexico, Div Res, Mexico City, Mexico
· Merck & Co Inc, Rahway, NJ, USA
· Hosp Gen Mexico, Mexico City, Mexico
· Univ Texas, Sch Publ Hlth, Houston, TX, USA
· Univ New S Wales, Dept Clin Pharmacol, Sydney, Australia
· St Vincents Hosp, Sydney, Australia
· Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Div Rheumatol, Sao Paulo, Brazil
· Univ Nottingham Hosp, Sch Med & Surg Sci, Div Gastroenterol, Nottingham, England
· Univ Maryland, Div Clin Immunol & Rheumatol, Baltimore, MD, USA
· Oslo City Dept Rheumatol, Oslo, Norway
· Diakonhjemmet Hosp, Oslo, Norway
· Northwestern Univ, Sch Med, Off Clin Res & Training, Chicago, IL, USA

***Article 3
Total Cites: 999
Article Title: Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis - The CLASS study: A randomized controlled trial
Authors: Silverstein, FE, Faich, G, Goldstein, JL, Simon, LS, Pincus, T, Whelton, A, Makuch, R, Eisen, G, Agarwal, NM, Stenson, WF, Burr, AM, Zhao, WW, Kent, JD, Lefkowith, JB, Verburg, KM, Geis, GS
Journal: JAMA-J AM MED ASSOC
Volume: 284
Page: 1247-1255
Year: 2000
Addresses: 
· Pharmacia Clin Res & Dev, Skokie, IL, USA
· Univ Washington, Dept Med, Seattle, WA, USA
· Pharmaceut Safety Assessments Inc, Narberth, PA, USA
· Univ Illinois, Coll Med, Dept Med, Sect Digest & Liver Dis, Chicago, IL, USA
· Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Rheumatol & Metab Bone Dis, Boston, MA, USA
· Vanderbilt Univ, Sch Med, Div Rheumatol & Immunol, Nashville, TN, USA
· Vanderbilt Univ, Sch Med, Div Gastroenterol, Nashville, TN, USA
· Johns Hopkins Univ, Dept Med, Baltimore, MD, USA
· Yale Univ, Dept Biostat, New Haven, CT, USA
· Duke Univ, Div Gastroenterol, Durham, NC, USA
· Washington Univ, Div Gastroenterol, St Louis, MO, USA

***Article 4
Total Cites: 886
Article Title: Role of cytokines in rheumatoid arthritis
Authors: Feldmann, M, Brennan, FM, Maini, RN
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 14
Page: 397-440
Year: 1996
Addresses: 
· HAMMERSMITH HOSP, MATHILDA & TERENCE KENNEDY INST RHEUMATOL, LONDON, ENGLAND

***Article 5
with Emery, P
with Smolen, JS
Total Cites: 817
Article Title: Infliximab and methotrexate in the treatment of rheumatoid arthritis
Authors: Lipsky, PE, van der Heijde, DMFM, St Clair, EW, Furst, DE, Breedveld, FC, Kalden, JR, Smolen, JS, Weisman, M, Emery, P, Feldmann, M, Harriman, GR, Maini, RN, Anti-tumor Necrosis Factor Trial
Journal: NEW ENGL J MED
Volume: 343
Page: 1594-1602
Year: 2000
Addresses: 
· Univ Texas, SW Med Ctr, Dallas, TX, USA
· Univ Hosp Maastricht, Maastricht, Netherlands
· Duke Univ, Med Ctr, Durham, NC, USA
· Virginia Mason Res Ctr, Seattle, WA, USA
· Leiden Univ, Leiden, Netherlands
· Inst Clin Immunol, Erlangen, Germany
· Univ Vienna, Vienna, Austria
· Univ Calif San Diego, San Diego, CA, USA
· Univ Leeds, Res Sch Med, Leeds, England
· Kennedy Inst Rheumatol, London, England
· Charing Cross Hosp, Imperial Coll, Sch Med, London, England
· Centocor Inc, Malvern, PA, USA

***Article 6
Total Cites: 816
Article Title: Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
Authors: Moreland, LW, Baumgartner, SW, Schiff, MH, Tindall, EA, Fleischmann, RM, Weaver, AL, Ettlinger, RE, Cohen, S, Koopman, WJ, Mohler, K, Widmer, MB, Blosch, CM
Journal: NEW ENGL J MED
Volume: 337
Page: 141-147
Year: 1997
Addresses: 
· PHYSICIANS CLIN SPOKANE, SPOKANE, WA, USA
· PORTLAND MED ASSOC, PORTLAND, OR, USA
· METROPLEX CLIN RES CTR, DALLAS, TX, USA
· ARTHRIT CTR NEBRASKA, LINCOLN, NE, USA
· IMMUNEX CORP, SEATTLE, WA, USA

***Article 7
Total Cites: 678
Article Title: Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial
Authors: Maini, R, St Clair, EW, Breedveld, F, Furst, D, Kalden, J, Weisman, M, Smolen, JS, Emery, P, Harriman, G, Feldmann, M, Lipsky, P, Attract Study Grp
Journal: LANCET
Volume: 354
Page: 1932-1939
Year: 1999
Addresses: 
· Kennedy Inst Rheumatol, London, England
· Charing Cross Hosp, Imperial Coll, Sch Med, London, England
· Duke Univ, Durham, NC, USA
· Leiden Univ, Leiden, Netherlands
· Virginia Mason Res Ctr, Seattle, WA, USA
· Inst Clin Immunol & Rheumatol, Erlangen, Germany
· Univ Calif San Diego, La Jolla, CA, USA
· Univ Vienna, Vienna, Austria
· Univ Leeds, Rheumatol & Rehabil Res Unit, Leeds, England
· Centocor Inc, Malvern, PA, USA
· Univ Texas, SW Med Ctr, Dallas, TX, USA

***Article 8
Total Cites: 671
Article Title: A trial of etanercept, a recombinant tumor necrosis factor receptor : Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
Authors: Weinblatt, ME, Kremer, JM, Bankhurst, AD, Bulpitt, KJ, Fleischmann, RM, Fox, RI, Jackson, CG, Lange, M, Burge, DJ
Journal: NEW ENGL J MED
Volume: 340
Page: 253-259
Year: 1999
Addresses: 
· Brigham & Womens Hosp, Boston, MA, USA
· Albany Med Coll, Albany, NY, USA
· Univ New Mexico, Sch Med, Albuquerque, NM, USA
· Univ Calif Los Angeles, Los Angeles, CA, USA
· Metroplex Clin Res Ctr, Dallas, TX, USA
· Scrips Clin, La Jolla, CA, USA
· Univ Utah, Med Ctr, Salt Lake City, UT, USA
· Immunex Corp, Seattle, WA, USA

***Article 9
Total Cites: 635
Article Title: AMERICAN-COLLEGE-OF-RHEUMATOLOGY PRELIMINARY DEFINITION OF IMPROVEMENT IN RHEUMATOID-ARTHRITIS
Authors: Felson, DT, Anderson, JJ, Boers, M, Bombardier, C, Furst, D, Goldsmith, C, Katz, LM, Lightfoot, R, Paulus, H, Strand, V, Tugwell, P, Weinblatt, M, Williams, HJ, Wolfe, F, Kieszak, S
Journal: ARTHRITIS AND RHEUMATISM
Volume: 38
Page: 727-735
Year: 1995
Addresses: 
· BOSTON UNIV, SCH MED, CTR ARTHRITIS, BOSTON, MA, USA
· UNIV LIMBURG HOSP, MAASTRICHT, NETHERLANDS
· UNIV TORONTO, WELLESLEY HOSP, TORONTO, CANADA
· VIRGINIA MASON MED CTR, SEATTLE, WA, USA
· MCMASTER UNIV, HAMILTON, CANADA
· US FDA, ROCKVILLE, MD, USA
· UNIV KENTUCKY, LEXINGTON, KY, USA
· UNIV CALIF LOS ANGELES, LOS ANGELES, CA, USA
· STANFORD UNIV, STANFORD, CA, USA
· BRIGHAM & WOMENS HOSP, BOSTON, MA, USA
· UNIV UTAH, SALT LAKE CITY, UT, USA
· ARTHRIT CTR, WICHITA, KS, USA

***Article 10
Total Cites: 545
Article Title: INHIBITION OF THE PRODUCTION AND EFFECTS OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN RHEUMATOID-ARTHRITIS
Authors: Arend, WP, Dayer, JM
Journal: ARTHRITIS AND RHEUMATISM
Volume: 38
Page: 151-160
Year: 1995
Addresses: 
· HOP CANTONAL UNIV GENEVA, GENEVA, SWITZERLAND

***Article 11
Total Cites: 545
Article Title: MISOPROSTOL REDUCES SERIOUS GASTROINTESTINAL COMPLICATIONS IN PATIENTS WITH RHEUMATOID-ARTHRITIS RECEIVING NONSTEROIDAL ANTIINFLAMMATORY DRUGS - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
Authors: Silverstein, FE, Graham, DY, Senior, JR, Davies, HW, Struthers, BJ, Bittman, RM, Geis, GS
Journal: ANNALS OF INTERNAL MEDICINE
Volume: 123
Page: 241-249
Year: 1995
Addresses: 
· GD SEARLE & CO, SKOKIE, IL, USA
· UNIV WASHINGTON, SCH MED, SEATTLE, WA, USA
· BAYLOR COLL MED, HOUSTON, TX, USA
· UNIV PENN, GASTROENTEROL SECT, PHILADELPHIA, PA, USA
· QUINTILES TRANSNATL CORP, RES TRIANGLE PK, NC, USA

***Article 12
Total Cites: 525
Article Title: A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
Authors: Bathon, JM, Martin, RW, Fleischmann, RM, Tesser, JR, Schiff, MH, Keystone, EC, Genovese, MC, Wasko, MC, Moreland, LW, Weaver, AL, Markenson, J, Finck, BK
Journal: NEW ENGL J MED
Volume: 343
Page: 1586-1593
Year: 2000
Addresses: 
· Johns Hopkins Univ, Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD, USA
· Michigan State Univ, Grand Rapids, MI, USA
· Metroplex Clin Res Ctr, Dallas, TX, USA
· Phoenix Ctr Clin Res, Phoenix, AZ, USA
· Denver Arthrit Clin, Denver, CO, USA
· Mt Sinai Hosp, Toronto, Canada
· Stanford Univ, Stanford, CA, USA
· Univ Pittsburgh, Med Ctr, Pittsburgh, PA, USA
· Univ Alabama, Birmingham, AL, USA
· Arthrit Ctr Nebraska, Lincoln, NE, USA
· Hosp Special Surg, New York, NY, USA
· Immunex Res & Dev Corp, Seattle, WA, USA

***Article 13
Total Cites: 509
Article Title: Etanercept therapy in rheumatoid arthritis - A randomized, controlled trial
Authors: Moreland, LW, Schiff, MH, Baumgartner, SW, Tindall, EA, Fleischmann, RM, Bulpitt, KJ, Weaver, AL, Keystone, EC, Furst, DE, Mease, PJ, Ruderman, EM, Horwitz, DA, Arkfeld, DG, Garrison, L, Burge, DJ, Blosch, CM, Lange, MLM, Mcdonnell, ND, Weinblatt, ME
Journal: ANNALS OF INTERNAL MEDICINE
Volume: 130
Page: 478-+
Year: 1999
Addresses: 
· Univ Alabama, Div Clin Immunol & Rheumatol, Arthrit Clin Intervent Program, Birmingham, AL, USA
· Denver Arthrit Clin, Denver, CO, USA
· Physicians Clin Spokane, Spokane, WA, USA
· Portland Med Associates, Portland, OR, USA
· Metroplex Clin Res Ctr, Dallas, TX, USA
· Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA, USA
· Univ So Calif, Sch Med, Los Angeles, CA, USA
· Arthrit Ctr Nebraska, Lincoln, NE, USA
· Mt Sinai Hosp, Ctr Adv Therapeut, Toronto, Canada
· Virginia Mason Med Ctr, Seattle, WA, USA
· Minor & James Med, Seattle, WA, USA
· Immunex Res & Dev Corp, Seattle, WA, USA
· Rush Med Coll, Chicago, IL, USA
· Brigham & Womens Hosp, Boston, MA, USA

***Article 14
Total Cites: 504
Article Title: Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
Authors: Maini, RN, Breedveld, FC, Kalden, JR, Smolen, JS, Davis, D, Macfarlane, JD, Antoni, C, Leeb, B, Elliott, MJ, Woody, JN, Schaible, TF, Feldmann, M
Journal: ARTHRITIS AND RHEUMATISM
Volume: 41
Page: 1552-1563
Year: 1998
Addresses: 
· Kennedy Inst Rheumatol, London, England
· Charing Cross & Westminster Med Sch, London, England
· Univ Leiden Hosp, Leiden, Netherlands
· Inst Clin Immunol & Rheumatol, Erlangen, Germany
· Lainz Hosp, Vienna, Austria
· Ludwig Boltzmann Inst Rheumatol, Vienna, Austria
· Centocor Inc, Malvern, PA, USA

***Article 15
Total Cites: 398
Article Title: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
Authors: Bresnihan, B, Alvaro-gracia, JM, Cobby, M, Doherty, M, Domljan, Z, Emery, P, Nuki, G, Pavelka, K, Rau, R, Rozman, B, Watt, I, Williams, B, Aitchison, R, Mccabe, D, Musikic, P
Journal: ARTHRITIS AND RHEUMATISM
Volume: 41
Page: 2196-2204
Year: 1998
Addresses: 
· St Vincents Hosp, Univ Dept Rheumatol, Dublin, Ireland
· Hosp Princesa, Madrid, Spain
· Frenchay Hosp, Bristol, England
· City Hosp, Nottingham, England
· Univ Zagreb, Ctr Clin, Zagreb, Croatia
· Leeds Gen Infirm, Leeds, England
· Univ Edinburgh, Edinburgh, Scotland
· Inst Rheumatol, Prague, Czech Republic
· Evangel Fachkrankenhaus, Ratingen, Germany
· Univ Ljubljana, Med Ctr, Ljubljana, Slovenia
· Bristol Royal Infirm, Bristol, England
· Univ Wales Hosp, Cardiff, Wales
· Amgen Inc, Boulder, CO, USA
· Amgen Inc, The Hague, Netherlands

***Article 16
Total Cites: 398
Article Title: Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis - A randomized controlled trial
Authors: Simon, LS, Weaver, AL, Graham, DY, Kivitz, AJ, Lipsky, PE, Hubbard, RC, Isakson, PC, Verburg, KM, Yu, SS, Zhao, WW, Geis, GS
Journal: JAMA-J AM MED ASSOC
Volume: 282
Page: 1921-1928
Year: 1999
Addresses: 
· Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div rheumatol & Metab Bone Dis, Boston, MA, USA
· Arthrit Ctr Nebraska, Lincoln, NE, USA
· Baylor Coll Med, Vet Affairs Med Ctr, Dept Med, Houston, TX, USA
· Altoona Ctr Clin Res, Altoona, PA, USA
· Univ Texas, SW Med Ctr, Div Rheumat Dis, Dallas, TX, USA
· Searle Res & Dev, Dept Clin Res, Skokie, IL, USA
· Searle Res & Dev, COX2 Technol, Skokie, IL, USA

***Article 17
Total Cites: 381
Article Title: MODIFIED DISEASE-ACTIVITY SCORES THAT INCLUDE 28-JOINT COUNTS - DEVELOPMENT AND VALIDATION IN A PROSPECTIVE LONGITUDINAL-STUDY OF PATIENTS WITH RHEUMATOID-ARTHRITIS
Authors: Prevoo, MLL, Vanthof, MA, Kuper, HH, Vanleeuwen, MA, Vandeputte, LBA, Vanriel, PLCM
Journal: ARTHRITIS AND RHEUMATISM
Volume: 38
Page: 44-48
Year: 1995
Addresses: 
· UNIV NIJMEGEN, NIJMEGEN, NETHERLANDS
· UNIV GRONINGEN HOSP, GRONINGEN, NETHERLANDS

***Article 18
Total Cites: 353
Article Title: COMBINATION THERAPY WITH CYCLOSPORINE AND METHOTREXATE IN SEVERE RHEUMATOID-ARTHRITIS
Authors: Tugwell, P, Pincus, T, Yocum, D, Stein, M, Gluck, O, Kraag, G, Mckendry, R, Tesser, J, Baker, P, Wells, G
Journal: NEW ENGL J MED
Volume: 333
Page: 137-141
Year: 1995
Addresses: 
· UNIV OTTAWA, CLIN EPIDEMIOL UNIT, OTTAWA, CANADA
· VANDERBILT UNIV, DIV RHEUMATOL & IMMUNOL, NASHVILLE, TN, USA
· UNIV ARIZONA, DIV RHEUMATOL & IMMUNOL, TUCSON, AZ, USA
· ARIZONA RHEUMATOL CTR, PHOENIX, AZ, USA

***Article 19
Total Cites: 352
Article Title: Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
Authors: Boers, M, Verhoeven, AC, Markusse, HM, vandelaar, MAFJ, Westhovens, R, vandenderen, JC, vanzeben, D, Dijkmans, BAC, Peeters, AJ, Jacobs, P, vandenbrink, HR, Schouten, HJA, vanderheijde, DMFM, Boonen, A, vanderlinden, S
Journal: LANCET
Volume: 350
Page: 309-318
Year: 1997
Addresses: 
· UNIV HOSP, MAASTRICHT, NETHERLANDS
· ZUIDERZIEKENHUIS, ROTTERDAM, NETHERLANDS
· MED SPECTRUM TWENTE, ENSCHEDE, NETHERLANDS
· TWENTEBORG HOSP, ENSCHEDE, NETHERLANDS
· CATHOLIC UNIV LEUVEN, PELLENBERG HOSP, LOUVAIN, BELGIUM
· JAN VAN BREEMEN INST, AMSTERDAM, NETHERLANDS
· BRONOVO HOSP, THE HAGUE, NETHERLANDS
· UNIV HOSP, LEIDEN, NETHERLANDS
· REINIER DE GRAAF GASTHUIS, DELFT, NETHERLANDS
· ST LAURENTIUS HOSP, ROERMOND, NETHERLANDS
· MED CTR ALKMAAR, ALKMAAR, NETHERLANDS

***Article 20
Total Cites: 352
Article Title: THE EFFECT OF GLUCOCORTICOIDS ON JOINT DESTRUCTION IN RHEUMATOID-ARTHRITIS
Authors: Kirwan, JR, Byron, M, Dieppe, P, Eastmond, C, Halsey, J, Hickling, P, Hollingworth, P, Jacoby, R, Kirk, A, Moran, C, Reid, D, Swannell, T, Yates, D, Cooper, C, George, E, Forbes, D, Jessop, J, Watt, I
Journal: NEW ENGL J MED
Volume: 333
Page: 142-146
Year: 1995
Addresses: 
· STOKE MANDEVILLE HOSP, AYLESBURY, ENGLAND
· CITY HOSP, ABERDEEN, SCOTLAND
· LANCASTER MOOR HOSP, LANCASTER, ENGLAND
· MT GOULD HOSP, PLYMOUTH, ENGLAND
· SOUTHMEAD GEN HOSP, BRISTOL, ENGLAND
· PRINCESS ELIZABETH HOSP, EXETER, ENGLAND
· AMERSHAM HOSP, AMERSHAM, ENGLAND
· CHRISTCHURCH HOSP, CHRISTCHURCH, NEW ZEALAND
· CITY HOSP, NOTTINGHAM, ENGLAND
· TAUNTON & SOMERSET HOSP, TAUNTON, ENGLAND