***Article 1
Total Cites: 2424
Article Title: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
Authors: Poltorak, A, He, XL, Smirnova, I, Liu, MY, Van Huffel, C, Du, X, Birdwell, D, Alejos, E, Silva, M, Galanos, C, Freudenberg, M, Ricciardi-castagnoli, P, Layton, B, Beutler, B
Journal: SCIENCE
Volume: 282
Page: 2085-2088
Year: 1998
Addresses:
· Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX, USA
· Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX, USA
· CNR, Cellular & Mol Pharmacol Ctr, Milan, Italy
· Max Planck Inst Immunbiol, Freiburg, Germany
· Univ Texas, SW Med Ctr, Howard Hughes Med Inst, 5323 Harry Hines Blvd, Dallas, TX, USA

***Article 2
Total Cites: 1940
Article Title: Immunobiology of dendritic cells
Authors: Banchereau, J, Briere, F, Caux, C, Davoust, J, Lebecque, S, Liu, YT, Pulendran, B, Palucka, K
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 18
Page: 767-+
Year: 2000
Addresses:
· Baylor Inst Immunol Res, Dallas, TX, USA
· Schering Plough, Lab Immunol Res, Dardilly, France
· DNAX, Inst Res, Dept Immunobiol, Palo Alto, CA, USA

***Article 3
Total Cites: 1712
Article Title: A Toll-like receptor recognizes bacterial DNA
Authors: Hemmi, H, Takeuchi, O, Kawai, T, Kaisho, T, Sato, S, Sanjo, H, Matsumoto, M, Hoshino, K, Wagner, H, Takeda, K, Akira, S
Journal: NATURE
Volume: 408
Page: 740-745
Year: 2000
Addresses:
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka, Japan
· Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Osaka, Japan
· Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Munich, Germany
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, 3-1 Yamada Oka, Osaka, Japan

***Article 4
Total Cites: 1148
Article Title: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
Authors: Takeuchi, O, Hoshino, K, Kawai, T, Sanjo, H, Takada, H, Ogawa, T, Takeda, K, Akira, S
Journal: IMMUNITY
Volume: 11
Page: 443-451
Year: 1999
Addresses:
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Japan
· Core Res Evolutional Sci & Technol Japan Sci, Suita, Japan
· Technol Corp, Suita, Japan
· Tohoku Univ, Sch Dent, Dept Microbiol & Immunol, Aoba Ku, Sendai, Japan
· Asahi Univ, Sch Dent, Dept Oral Microbiol, Gifu, Japan
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, 3-1 Yamada Oka, Suita, Japan

***Article 5
Total Cites: 1147
Article Title: Innate immune recognition
Authors: Janeway, CA, Medzhitov, R
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 20
Page: 197-216
Year: 2002
Addresses:
· Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT, USA
· Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT, USA
· Yale Univ, Sch Med, Immunobiol Sect, 333 Cedar St, New Haven, CT, USA

***Article 6
with Alexopoulou, L
Total Cites: 1134
Article Title: Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3
Authors: Alexopoulou, L, Holt, AC, Medzhitov, R, Flavell, RA
Journal: NATURE
Volume: 413
Page: 732-738
Year: 2001
Addresses:
· Immunobiol Sect, New Haven, CT, USA
· Dept Mol Cellular & Dev Biol, New Haven, CT, USA
· Howard Hughes Med Inst, New Haven, CT, USA
· Yale Univ, Sch Med, New Haven, CT, USA

***Article 7
Total Cites: 1111
Article Title: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
Authors: Hoshino, K, Takeuchi, O, Kawai, T, Sanjo, H, Ogawa, T, Takeda, Y, Takeda, K, Akira, S
Journal: JOURNAL OF IMMUNOLOGY
Volume: 162
Page: 3749-3752
Year: 1999
Addresses:
· Hyogo Coll Med, Dept Biochem, Nishinomiya, Japan
· Int Med Ctr Japan, Inst Res, Tokyo, Japan
· Asahi Univ, Sch Dent, Dept Oral Microbiol, Gifu, Japan
· Japan Sci & Technol Corp, Core Res Evolutional Sci & Technol, Tokyo, Japan
· Hyogo Coll Med, Dept Biochem, 1-1 Mukogawa Cho, Nishinomiya, Japan

***Article 8
Total Cites: 1096
Article Title: Toll-like receptors: critical proteins linking innate and acquired immunity
Authors: Akira, S, Takeda, K, Kaisho, T
Journal: NATURE IMMUNOLOGY
Volume: 2
Page: 675-680
Year: 2001
Addresses:
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka, Japan
· Japan Sci & Technol Corp, SORST, Tokyo, Japan

***Article 9
Total Cites: 1079
Article Title: Toll-like receptors
Authors: Takeda, K, Kaisho, T, Akira, S
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 21
Page: 335-376
Year: 2003
Addresses:
· Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Japan
· Japan Sci & Technol Corp, Solut Oriented Res Sci & Technol, Suita, Japan
· RIKEN, Res Ctr Allergy & Immunol, Suita, Japan
· Osaka Univ, Res Inst Microbial Dis, Dept Host Def, 2-2 Yamadaoka, Suita, Japan

***Article 10
Total Cites: 956
Article Title: Toll-like receptors in the induction of the innate immune response
Authors: Aderem, A, Ulevitch, RJ
Journal: NATURE
Volume: 406
Page: 782-787
Year: 2000
Addresses:
· Univ Washington, Dept Immunol, Seattle, WA, USA
· Scripps Res Inst, Dept Immunol, La Jolla, CA, USA

***Article 11
Total Cites: 831
Article Title: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
Authors: Kyriakis, JM, Avruch, J
Journal: PHYSIOLOGICAL REVIEWS
Volume: 81
Page: 807-869
Year: 2001
Addresses:
· Massachusetts Gen Hosp E, Diabet Res Lab, Med Serv, Charlestown, MA, USA
· Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA, USA
· Harvard Univ, Sch Med, Dept Med, Boston, MA, USA
· Massachusetts Gen Hosp E, Diabet Res Lab, Med Serv, 149 13th St, Charlestown, MA, USA

***Article 12
Total Cites: 775
Article Title: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Authors: Hayashi, F, Smith, KD, Ozinsky, A, Hawn, TR, Yi, EC, Goodlett, DR, Eng, JK, Akira, S, Underhill, DM, Aderem, A
Journal: NATURE
Volume: 410
Page: 1099-1103
Year: 2001
Addresses:
· Inst Syst Biol, Seattle, WA, USA
· Univ Washington, Dept Immunol, Seattle, WA, USA
· Univ Washington, Dept Pathol, Seattle, WA, USA
· Univ Washington, Div Allergy & Infect Dis, Seattle, WA, USA
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Japan
· Inst Syst Biol, 4225 Roosevelt Way NE,Suite 200, Seattle, WA, USA

***Article 13
Total Cites: 765
Article Title: Toll-like receptor signalling
Authors: Akira, S, Takeda, K
Journal: NATURE REVIEWS IMMUNOLOGY
Volume: 4
Page: 499-511
Year: 2004
Addresses:
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka, Japan
· Japan Sci & Technol Agcy, ERATO, Osaka, Japan
· Kyushu Univ, Dept Mol Genet, Med Inst Bioregulat, Higashi Ku, Fukuoka, Japan
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, 3-1 Yamada Oka, Osaka, Japan

***Article 14
Total Cites: 757
Article Title: Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)
Authors: Qureshi, ST, Lariviere, L, Leveque, G, Clermont, S, Moore, KJ, Gros, P, Malo, D
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Volume: 189
Page: 615-625
Year: 1999
Addresses:
· McGill Univ, Dept Med, Montreal, Canada
· McGill Univ, Dept Biochem, Montreal, Canada
· McGill Univ, Dept Human Genet, Montreal, Canada
· Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, Canada
· Millennium Pharmaceut Inc, Cambridge, MA, USA
· Montreal Gen Hosp, Ctr Study Host Resistance, 1650 Cedar Ave,Rm L11-144, Montreal, Canada

***Article 15
Total Cites: 752
Article Title: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Authors: Yang, RB, Mark, MR, Gray, A, Huang, A, Xie, MH, Zhang, M, Goddard, A, Wood, WI, Gurney, AL, Godowski, PJ
Journal: NATURE
Volume: 395
Page: 284-288
Year: 1998
Addresses:
· Genentech Inc, Dept Mol Biol, S San Francisco, CA, USA

***Article 16
Total Cites: 717
Article Title: CpG motifs in bacterial DNA and their immune effects
Authors: Krieg, AM
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 20
Page: 709-760
Year: 2002
Addresses:
· Dept Vet Affairs Med Ctr, Iowa City, IA, USA
· Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA, USA
· Coley Pharmaceut Grp, Wellesley, MA, USA

***Article 17
Total Cites: 702
Article Title: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
Authors: Brightbill, HD, Libraty, DH, Krutzik, SR, Yang, RB, Belisle, JT, Bleharski, JR, Maitland, M, Norgard, MV, Plevy, SE, Smale, ST, Brennan, PJ, Bloom, BR, Godowski, PJ, Modlin, RL
Journal: SCIENCE
Volume: 285
Page: 732-736
Year: 1999
Addresses:
· Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA, USA
· Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA, USA
· Univ Calif Los Angeles, Sch Med, Div Dermatol, Los Angeles, CA, USA
· Univ Calif Los Angeles, Sch Med, Dept Med, Div Infect Dis, Los Angeles, CA, USA
· Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Los Angeles, CA, USA
· Genentech Inc, S San Francisco, CA, USA
· Colorado State Univ, Dept Microbiol, Ft Collins, CO, USA
· Yeshiva Univ Albert Einstein Coll Med, Howard Hughes Med Inst, Bronx, NY, USA
· Univ Texas, SW Med Ctr, Dallas, TX, USA
· CUNY Mt Sinai Sch Med, Ctr Immunol, New York, NY, USA
· Harvard Univ, Sch Publ Hlth, Off Dean, Boston, MA, USA

***Article 18
Total Cites: 697
Article Title: A family of human receptors structurally related to Drosophila Toll
Authors: Rock, FL, Hardiman, G, Timans, JC, Kastelein, RA, Bazan, JF
Journal: P NATL ACAD SCI USA
Volume: 95
Page: 588-593
Year: 1998
Addresses:
· DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA, USA
· DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, 901 Calif Ave, Palo Alto, CA, USA

***Article 19
Total Cites: 685
Article Title: Plant pathogens and integrated defence responses to infection
Authors: Dangl, JL, Jones, JDG
Journal: NATURE
Volume: 411
Page: 826-833
Year: 2001
Addresses:
· Univ N Carolina, Dept Biol, Chapel Hill, NC, USA
· Univ N Carolina, Curriculum Genet, Chapel Hill, NC, USA
· John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich, England
· Univ N Carolina, Dept Biol, Coker Hall 108,CB 3280, Chapel Hill, NC, USA

***Article 20
Total Cites: 677
Article Title: MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
Authors: Shimazu, R, Akashi, S, Ogata, H, Nagai, Y, Fukudome, K, Miyake, K, Kimoto, M
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Volume: 189
Page: 1777-1782
Year: 1999
Addresses:
· Saga Med Sch, Dept Immunol, Saga, Japan